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Oxygen is the most important source for the survival of all living organisms. Our daily activities require energy and it comes from the food we consume when the oxygen present in our blood burns that food. The deficiency of oxygen disturbs the entire functioning of organs in the body. Around 50-80% of the natural oxygen production on Earth comes from the ocean. The oxygen production from ocean is the result of drifting plants, algae, and some bacteria that can photosynthesize. Oxygen has many applications like chemical processing, medical application, and many more. Different types of methods are available to produce oxygen at a considerable scale, e.g., cryogenic, pressure swing, electrochemical. In this article, we discuss the stepwise process of various methods to produce oxygen and the challenges associated with details. © 2022 National Institute of Science Communication and Information Resources (NISCAIR). All rights reserved.
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Decarbonization of the aviation sector is crucial to reaching the global climate targets. We quantified the environmental impacts of Power-to-Liquid kerosene produced via Fischer-Tropsch Synthesis from electricity and carbon dioxide from air as one broadly discussed alternative liquid jet fuel. We applied a life-cycle assessment considering a well-to-wake boundary for five impact categories including climate change and two inventory indicators. Three different electricity production mixes and four different kerosene production pathways in Germany were analyzed, including two Direct Air Capture technologies, and compared to fossil jet fuel. The environmental impacts of Power-to-Liquid kerosene varied significantly across the production pathways. E.g., when electricity from wind power was used, the reduction in CO2-eq. compared to fossil jet fuel varied between 27.6–46.2% (with non-CO2 effects) and between 52.6–88.9% (without non-CO2 effects). The reduction potential regarding CO2-eq. of the layout using low-temperature electrolysis and high-temperature Direct Air Capture was lower compared to the high-temperature electrolysis and low-temperature Direct Air Capture. Overall, the layout causing the lowest environmental impacts uses high-temperature electrolysis, low-temperature Direct Air Capture and electricity from wind power. This paper showed that PtL-kerosene produced with renewable energy could play an important role in decarbonizing the aviation sector.
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Objective: ACE2, part of the counterregulatory arm of the ennin-angiotensin system, serves both as protective toward oxidative stress and cardiovascular ennin ling and as key entry for SARS-CoV-2. ACE2 has two isoforms, non-glycosylated and glycosylated, being this latter accountable for the binding with SARS-CoV-2. After the binding, viruses use proteases as cathepsin-L (Cat-L) to entry the cells. Both ACE2 glycosylation and Cat-L activity are pH-dependent. Gitelman and Bartter syndromes (GS/BS), rare genetic tubulopathies, are characterized by electrolytic alterations, activation of the ennin-angiotensin system, yet normo-hypotension, increased levels of ACE2 and metabolic alkalosis with likely increased intracellular pH. We reported that during the first wave of COVID-19 in early 2020 none of our cohort of 128 GS/BS patients from the major hotspots in Northern Italy had been infected or suffered any major COVID-19 symptoms and in a second survey on the same cohort in 2021 we reported only 8 positives, 4 asymptomatic and 4 with very light symptoms This study aims to investigate potential mechanisms as ACE2 glycosylation and Cat-L activity related to patients' metabolic alkalosis and viral entry/infection. Design and method: Mononuclear cells ACE2 glycosylation (Western blot) and blood Cat-L activity (ELISA) from 20 GS/BS patients have been compared to those from 15 heathy subjects. Results: Non-glycosylated ACE2 was higher in GS/BS (0.82 ± 0.19 d.u. vs 0.67 ± 0.13 p = 0.01);glycosylated ACE2 was not different (0.85 ± 0.28 in GS/BS vs 0.73 ± 0.23 p = 0.19). Cat-L activity was lower in GS/BS (3.90 ± 1.13 r.f.u. vs 5.31 ± 0.8 p < 0.001) and inversely correlated with blood bicarbonate (HCO3-), while a negative correlation between glycosylated ACE2 and HCO3- approaches statistical significance (p = 0.08). Conclusions: GS/BS's metabolic alkalosis, likely by increasing intracellular pH, influences the glycosylation of ACE2 and the activity of Cat-L, providing a mechanistic explanation for the near complete absence of COVID-19 or its symptoms reported in our cohort. These findings provide a rationale for pursuing the identification and/or synthesis of new drugs that specifically target ACE2 glycosylation and/or proteases involved in SARS-CoV-2 infection.
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Background and importance Isavuconazole is a new antifungal triazole authorised for invasive aspergillosis and mucormycosis. It is a therapeutic alternative to voriconazole and liposomal amphotericin B for invasive aspergillosis, and to liposomal amphotericin B in mucormycosis. Aim and objectives To analyse prescription characteristics of isavuconazole in patients with COVID-19 in an intensive care unit (ICU) as well as its effectiveness and safety. Material and methods A cross-sectional, observational study was conducted (June 2020-April 2021). Patients with COVID-19 in an ICU on treatment with isavuconazole were included. Electronic prescription program and clinical history were used to collect the following data: sex, age, comorbidities, coinfection with other pathogens in addition to SARS-CoV-2, type of therapy (empirical/targeted), duration and previous azole treatment (yes/no). Effectiveness was evaluated by symptoms resolution, reasons for treatment suspension and status (alive/death) 30 days after completion of treatment. Safety was assessed according to adverse events (AE). Results Thirty-three patients (54.5% men) with mean age of 61 (35-77) years were evaluated. Twenty-nine patients (87.9%) had comorbidities, the most frequent were: hypertension (19.1%), dyslipidaemia (12.8%), obesity (11.7%) and diabetes (8.5%). Thirty-two (96.9%) had coinfections, with a mean of 1.8 (SD 1.2) infections/patient. The most implicated pathogens were: Acinetobacter baumanii (18.8%), Candida albicans (11.6%) and Aspergillus fumigatus (8.7%). Twentythree patients (69.7%) received isavuconazole as empirical therapy and 10 (30.3%) as targeted. Mean duration of treatment was 12.3 (SD 7.5) days. Twenty-five (75.6%) patients had not previously received azole treatment, 7 (21.3%) had received voriconazole and 1 (3%) fluconazole. Symptoms resolution was observed in 12 (36.4%) cases. Seven patients (21.2%) discontinued treatment due to negative culture, 12 (36.4%) due to symptoms resolution and 14 (42.4%) due to death. At 30 days completion of treatment, 15 patients (45.5%) remained alive and 18 (54.5%) had died. AE were recorded in 6 cases (18.2%): liver disorders (n=4) and electrolytic alterations (n=2). Conclusion and relevance Most patients presented comorbidities and coinfections in addition to COVID-19. Effectiveness of isavuconazol was adequate in approximately one-third of patients, despite the high severity and clinical complexity. Approximately half the patients remained alive at 30 days following completion of treatment. Isavuconazol was well tolerated in most cases.
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BACKGROUND AND AIMS: ACE2, part of the counter-regulatory arm of the renin-angiotensin system, serves both as protective toward oxidative stress and cardiovascular remodeling and as a key entry for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). ACE2 has two isoforms, non-glycosylated and glycosylated, the latter being accountable for the binding with SARS-CoV-2. After the binding, viruses use proteases as cathepsin-L (Cat-L) to entry the cells. Both ACE2 glycosylation and Cat-L activity are pH-dependent. Gitelman and Bartter syndromes (GS/BS), rare genetic tubulopathies, are characterized by electrolytic alterations, activation of the renin-angiotensin system, yet normo-hypotension, increased levels of ACE2 and metabolic alkalosis with likely increased intracellular pH. We reported that during the first wave of COVID-19 in early 2020 none of our cohort of 128 GS/BS patients from the major hotspots in Northern Italy had been infected or suffered any major COVID-19 symptoms and in a second survey on the same cohort in 2021, we reported only eight positives, four asymptomatic and four with very light symptoms This study aims to investigate potential mechanisms as ACE2 glycosylation and Cat-L activity related to patients' metabolic alkalosis and viral entry/infection. METHOD: Mononuclear cells ACE2 glycosylation (Western blot) and blood Cat-L activity (ELISA) from 20 GS/BS patients have been compared with those from 15 healthy subjects. RESULTS: Non-glycosylated ACE2 was higher in GS/BS (0.82 ± 0.19 d.u. versus 0.67 ± 0.13, P = 0.01);glycosylated ACE2 was not different (0.85 ± 0.28 in GS/BS versus 0.73 ± 0.23, P = 0.19). Cat-L activity was lower in GS/BS (3.90 ± 1.13 r.f.u. versus 5.31 ± 0.8, P <0 0.001) and inversely correlated with blood bicarbonate (HCO3 -), while a negative correlation between glycosylated ACE2 and HCO3 - approaches statistical significance (P = 0.08). CONCLUSION: GS/BS's metabolic alkalosis, likely by increasing intracellular pH, influences the glycosylation of ACE2 and the activity of Cat-L, providing a mechanistic explanation for the near-complete absence of COVID-19 or its symptoms reported in our cohort. These findings provide a rationale for pursuing the identification and/or synthesis of new drugs that specifically target ACE2 glycosylation and/or proteases involved in SARS-CoV-2 infection.
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A multi-faceted energy intensive technology that can be used for water disinfection and synthesis of electrolysed water (EW) is the need of the hour to achieve a sustainable post COVID 19 water management strategy. Direct sunlight driven processes are legislatively green technologies and hold the key in environmental sustenance. The development of a laboratory proto type reactor powered by a photovoltaic module for the treatment open source river water is described in this paper. This paper reports on the efficacy of the developed proto type technology for multipurpose application namely: (1) the production of Electrolysed water (EW) in a cost efficient manner using direct sunlight and (2) the removal of organic impurity from water using direct sunlight without the use of any photo catalyst or membrane. The prototype reactor utilizes chemical spray pyrolysis deposited highly photo-conducting indium sulphide thin films grown on fluorine doped tin oxide (F:SnO2) substrate (coated using chemical spray pyrolysis technique in-house) as the photo electrode. Dissolved organic matter arising in river water has distinctive fluorescence properties, and this research has utilized it to identify dissolved organic substances in both random samples and treated water. The work proves that photovoltaic module powered electrolytic reactors consisting of In2S3 electrodes can be used for treatment of river water. A diaphragm free, energy intensive route for the production of electrolysed water with the use of non-hazardous NaCl as the electrolyte has been demonstrated here. We conclude that In2S3 electrodes can be used for non-photo catalytic reduction of humic-derived impurities in river water. These results are also encouraging on the prospects of treating Nitrates present in the river water. The likes of techniques as described in this report that do not use photo catalyst or membranes may pave way for real time photovoltaic module powered floating reactors that can decontaminate water bodies on a large scale. The technique used by us demonstrates that a chlorine free route can be optimized for the synthesis of EW eliminating the production of large amounts of wastewater with high levels of biological oxygen demand (BOD).
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Pure oxygen is vital in medical treatment, first aid, and chemical synthesis. Hypoxia can cause severe damage to the organ systems such as respiratory, digestive, and nervous systems and even directly cause death. Notably, the severe Coronavirus disease 2019 (COVID-19) pandemic has exacerbated the shortage of medical oxygen in the world. Hence, a safe, economical, and portable oxygen supply device is urgently needed. Here, we have successfully prepared a device with air-breathing electrochemical extraction of pure oxygen (ABEEPO) with light weight and high energy efficiency. By renovating the structure of the electrolytic cell, the components bipolar plate and end plate are replaced with a plastic membrane, and the component current collector is replaced with a highly conductive graphene composite membrane electrode. Due to the use of the plastic membrane and graphene composite membrane electrode, the weight of the electrolytic cell is reduced from 1319.4 to 1.6 g, and the flexibility of the electrolytic cell is successfully realized. Through optimizing anode catalysts, working area, and operating voltage, a high flow rate per mass (234 mL h-1 g-1) was achieved at a voltage of 1.2 V. The device exhibits high stability in 2 h. The new portable oxygen production device would be effective for hypoxia treatment.
Subject(s)
COVID-19 , Graphite , Humans , Hypoxia , Oxygen/chemistry , PlasticsABSTRACT
The use of harmful alcohol-based disinfectants and sanitizers was a major concern throughout the CoVID-19 era. Frequent use of alcohol-based sanitizer can dry up the skin, and the effect is worsening for individuals with sensitive skin. Alcohol-based disinfectants are flammable and can ignite if used near a flame, spark, or other source of ignition. Using the electrolysis of sodium chloride (NaCl) aqueous solution method, this study aims to make Hypochlorous Acid (HOCl), a safe disinfectant and sanitizer. Two critical parameters were tested on the electrolysis effect of producing HOCl. The first is the amount of sodium chloride (NaCl) present, while the second is the type of electrode used, which are carbon, graphite, and titanium. The results showed that 10 grams of NaCl produces 50-200 ppm of HOCl, which is good for sanitizing purposes, and 30 grams of NaCl produces 500-800 ppm of HOCl, which is good for disinfecting purposes. The graphite electrode was also demonstrated to be capable of producing a clean HOCl solution. Using a UV-vis spectrophotometer, the effectiveness of the HOCl produced was determined, and it was discovered that HOCl is capable of killing bacteria. As a result, HOCl can be applied as a safe disinfectant and sanitizer in the fight against COVID-19.
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Wearing facemasks, face shields and social distancing are some of health protocols that are being imposed to lessen the risk of viral transmission specifically COVID 19. All establishments here in the Philippines build their own sanitation booths to ensure virus prevention. This study aims to address the issues regarding the use of chemical disinfectants and manually placing them in sanitation booths, and the ineffective manual ways of sanitizing individuals. This study is a design project adopting the developmental type of research method. Hypochlorous acid (HOCL) has a lot of potential as a disinfectant. In an electrolysis chamber with dilute salt and distilled water, HOCL can be made. The researchers design a device to automate the manufacturing of HOCL, which will be use as disinfectant, and automatically sanitize individuals with a safer and non-toxic disinfectant. The researchers prepared questionnaires to assess the acceptability of the device. The statistical tool used in the interpretation of data is weighted arithmetic mean. The major finding of this study is the ability of the device to convert distilled water and salt into disinfectant solution with the electrolysis process utilized, the duration of the process that will optimally convert it is 40 minutes, with accurate reading of analog pH sensor and lessen the exposure to each individual through the automation of the sanitation booth. For that reason, the researchers conclude that this design project provides a way to ensure virus prevention using automatic sanitation booth with disinfectant (HOCL) solution that offers more benefits over traditional sanitation methods. The overall acceptability rating of the design project is 4.46, interpreted as Very Good which shows that the device has high satisfaction. © 2021 IEEE.
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Featured ApplicationThis study shows the use of a by-product from the manufacture of a novel antiseptic/disinfectant (HOCl) to obtain a protein isolate from defatted soybean flour (a co-product from the soybean oil industry);an optimization process was carried out to create an industrial symbiosis.Defatted soybean flour is generated during the oil extraction process of soybean, and it has a protein content of ~50%. On the other hand, an alkaline solution of NaOH is produced during the electrolysis process of NaCl in a novel method used to make a potent disinfectant/antiseptic (HOCl). In the present work, we suggest using these two products to produce soy protein isolate (SPI), aiming to create an industrial symbiosis. A Box–Behnken experimental design was executed, and a surface response analysis was performed to optimize temperature, alkaline solution, and time used for SPI extraction. The SPI produced at optimal conditions was then characterized. The experimental results fit well with a second-order polynomial equation that could predict 93.15% of the variability under a combination of 70 °C, alkaline solution 3 (pH 12.68), and 44.7 min of the process. The model predicts a 49.79% extraction yield, and when tested, we obtained 48.30% within the confidence interval (46.66–52.93%). The obtained SPI was comparable in content and structure with a commercial SPI by molecular weight and molecular spectroscopy characterization. Finally, the urease activity (UA) test was negative, indicating no activity for trypsin inhibitor. Based on the functional properties, the SPI is suitable for food applications.
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The world is undergoing a substantial energy transition with an increasing share of intermittent sources of energy on the grid, which is increasing the challenges to operate the power grid reliably. An option that has been receiving much focus after the COVID pandemic is the development of a hydrogen economy. Challenges for a hydrogen economy are the high investment costs involved in compression, storage, and long-distance transportation. This paper analyses an innovative proposal for the creation of hydrogen ocean links. It intends to fill existing gaps in the creation of a hydrogen economy with the increase in flexibility and viability for hydrogen production, consumption, compression, storage, and transportation. The main concept behind the proposals presented in this paper consists of using the fact that the pressure in the deep sea is very high, which allows a thin and cheap HDPE tank to store and transport large amounts of pressurized hydrogen in the deep sea. This is performed by replacing seawater with pressurized hydrogen and maintaining the pressure in the pipes similar to the outside pressure. Hydrogen Deep Ocean Link has the potential of increasing the interconnectivity of different regional energy grids into a global sustainable interconnected energy system.
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An increase in human activities and population growth have significantly increased the world's energy demands. The major source of energy for the world today is from fossil fuels, which are polluting and degrading the environment due to the emission of greenhouse gases. Hydrogen is an identified efficient energy carrier and can be obtained through renewable and non-renewable sources. An overview of renewable sources of hydrogen production which focuses on water splitting (electrolysis, thermolysis, and photolysis) and biomass (biological and thermochemical) mechanisms is presented in this study. The limitations associated with these mechanisms are discussed. The study also looks at some critical factors that hinders the scaling up of the hydrogen economy globally. Key among these factors are issues relating to the absence of a value chain for clean hydrogen, storage and transportation of hydrogen, high cost of production, lack of international standards, and risks in investment. The study ends with some future research recommendations for researchers to help enhance the technical efficiencies of some production mechanisms, and policy direction to governments to reduce investment risks in the sector to scale the hydrogen economy up.
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With the emergence of Covid-19, as more people got affected by the fatal disease, the demand for a device to measure the oxygen content in our body has grown up. Due to unavailability of effective treatments, the outcome for critically ill Covid-19 patients depends on the availability of supportive medical care. In the current scenario of limited resources, it is important to identify patients who require close monitoring and serious care, including supplementary oxygen. The rapid spread of this virus as a global pandemic has brought in prodigious challenges to the healthcare system. Several oximeters are currently available on the market that can be utilized for this purpose. However, because they are powered by batteries, their performance degrades over time as the battery drains. In comparison to the widely utilized IR sensor in pulse oximeters, the MAX sensor employed in the suggested device is better. During the second wave of Covid-19, as more people got affected by this life-threatening illness, India witnessed a surge in the demand for oxygen supply. In light of this, apart from the oximeter, we have also suggested a methodology to construct a DIY oxygen generator that can be made using easily available materials in case of an emergency. Water has a chemical formula H2O which can be broken into its constitutional elements H2 and O2. Water is already rich in hydroxide ions but adding sodium bicarbonate as a catalyst raises the OH-concentration even more, allowing it to be utilized as an electrolyte. This paper aims to design a technique to develop both these devices cost-effectively and reliably. © 2021 IEEE.